In the United States invasive species are one of the leading causes of native species requiring federal protection under the Endangered Species Act (ESA). Our goal was to document the impacts of invasive species on Threatened and Endangered (T&E) animal species in the US. To quantify these impacts, we reviewed Federal Register listing decisions published by the United States Fish and Wildlife Service and National Marine Fisheries Services for all animals listed under the ESA from 1975 through 2021.