Studies Toward 3,4-Dihydro-2(1H)-quinolinone Derivatives
From Yongyu Ou on April 20th, 2020
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Hunanamycin A—our inspiration for this project—is a natural product of marine bacterium, Bacillus hunanensis, discovered in the mangrove swamp in the Bahamas, by MacMillan et al. We are currently synthesizing various aniline derivatives by using amide formation followed by Lewis acid catalyzed cyclization to form the quinolinone core structure with R groups attach to different positions of the aromatic ring. When all quinolinone core structure has been accessed, they will test for biological studies.